He's Drunk:
Does Your Self-Defense System Rely Too Much on Pain Compliance?

According to the Department of Justice, about 64% of criminals arrested are under the influence of alcohol or drugs during the commission of their crime.

However, I have found in my experience that it seems that about three of every four people you end up fighting are high on something.  If they weren’t, I seriously doubt that the situation would degenerate into a fight…

The ugly truth of most sexual assaults is that there is alcohol involved – usually on both sides of the equation.

So, you should give some thought to how you would handle an attacker who was drunk or high on something.  You should also give some thought as to how you are going to defend yourself if you are drunk.

Okay, because the guy is high many of your techniques designed to hurt him probably won't work because the drugs in his system are inhibiting the pain signals from reaching his brain.  The "stun and run", "kick him in the groin" or "poke him in the eyes" techniques might not work as well as they did in the gym.

Now what do you do?

This is an important point here – the method that you should learn should not rely on him feeling or reacting to pain.   Look for a method that controls his center line while physically moving him off of you or effecting a mechanical knockout or mechanical damage to his joints. 

You also want to be learning concepts and principals that use gross body movements.  You want something that is simple and does not require fine motor skills.  Those will probably be shot because of stress and especially if you have been drinking yourself.